Differences in collagen gene expression in male and female Anterior Cruciate Ligament injured athletes

X. Liu, T. Tingle, David M. Lintner, W. R. Lowe, Q. J. Zhai, Z. P. Luo

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Anterior Cruciate Ligament (ACL) injuries occur two to eight times more frequently in women than men. However, it remains unclear whether gender differences exist in ACL at the molecular level. Using reverse transcript polymerase chain reaction (RT-PCR) with histological analysis, the gene expressions of collagen types I and III of fibroblasts from ACLs of 17 male and 17 female athletes with acute ACL tears were studied. Female athletes were found to have a significantly lower gene expression of collagen I. No significant difference was found in type III collagen gene expression between male and female athletes. This finding may help us to explain the higher incidence of ACL injury in female athletes from the molecular perspective.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalBiology of Sport
Volume26
Issue number3
DOIs
StatePublished - Jan 1 2009

Keywords

  • Anterior cruciate ligament (ACL)
  • Collagen
  • Gene expression
  • RT-PCR

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Physiology (medical)

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