TY - JOUR
T1 - Dietary saturated fatty acids
T2 - A novel treatment for alcoholic liver disease
AU - Nanji, Amin A.
AU - Hossein Sadrzadeh, S. M.
AU - Yang, Eun K.
AU - Fogt, Franz
AU - Meydani, Mohsen
AU - Dannenberg, Andrew J.
PY - 1995/8
Y1 - 1995/8
N2 - Background & Aims: Lipid peroxidation may be important in the pathogenesis of alcoholic liver injury. The purpose of this study was to determine whether a saturated fatty acid-based therapy (palm oil) could decrease lipid peroxidation and alcoholic liver injury during ethanol withdrawal. Methods: Three groups of male Wistar rats (5 rats/group) were studied. Rats in group 1 were fed a fish oil-ethanol diet for 6 weeks; rats in groups 2 and 3 were fed a fish oil-ethanol diet for 6 weeks before treatment with fish oil-dextrose (group 2) or palm oil-dextrose (group 3) for 2 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, fatty acid composition, cytochrome P450 2E1 activity, and tocopherol levels. Results: By 6 weeks, all rats had developed fatty liver, inflammation, and necrosis. Group 2 showed minimal histological improvement, whereas group 3 showed near normalization of the histology. The improvement in group 3 was associated with decreased lipid peroxidation and P450 2E1 activity. Higher levels of ω-3 fatty acids were detected in group 2 than group 3. Tocopherol levels were similar among the groups. Conclusions: A diet enriched in saturated but not unsaturated fatty acids reversed alcoholic liver injury. This effect may be explained by down-regulation of lipid peroxidation.
AB - Background & Aims: Lipid peroxidation may be important in the pathogenesis of alcoholic liver injury. The purpose of this study was to determine whether a saturated fatty acid-based therapy (palm oil) could decrease lipid peroxidation and alcoholic liver injury during ethanol withdrawal. Methods: Three groups of male Wistar rats (5 rats/group) were studied. Rats in group 1 were fed a fish oil-ethanol diet for 6 weeks; rats in groups 2 and 3 were fed a fish oil-ethanol diet for 6 weeks before treatment with fish oil-dextrose (group 2) or palm oil-dextrose (group 3) for 2 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, fatty acid composition, cytochrome P450 2E1 activity, and tocopherol levels. Results: By 6 weeks, all rats had developed fatty liver, inflammation, and necrosis. Group 2 showed minimal histological improvement, whereas group 3 showed near normalization of the histology. The improvement in group 3 was associated with decreased lipid peroxidation and P450 2E1 activity. Higher levels of ω-3 fatty acids were detected in group 2 than group 3. Tocopherol levels were similar among the groups. Conclusions: A diet enriched in saturated but not unsaturated fatty acids reversed alcoholic liver injury. This effect may be explained by down-regulation of lipid peroxidation.
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U2 - 10.1016/0016-5085(95)90344-5
DO - 10.1016/0016-5085(95)90344-5
M3 - Article
C2 - 7615205
AN - SCOPUS:0029099274
VL - 109
SP - 547
EP - 554
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 2
ER -