TY - JOUR
T1 - Dietary fat intake and risk of coronary heart disease
T2 - The Strong Heart Study
AU - Xu, Jiaqiong
AU - Eilat-Adar, Sigal
AU - Loria, Catherine
AU - Goldbourt, Uri
AU - Howard, Barbara V.
AU - Fabsitz, Richard R.
AU - Zephier, Ellie M.
AU - Mattil, Claudia
AU - Lee, Elisa T.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Background: The results of previous studies on the association between dietary fat intake and coronary heart disease (CHD) incidence are inconsistent. Objective: The aim of this study was to examine the association between dietary fat intake and CHD incidence in American Indians in the Strong Heart Study. Design: A total of 2938 participants aged 47-79 y and free of CHD at the second examination (1993-1995) were examined and followed for CHD, nonfatal CHD, and fatal CHD events to 31 December 2002. Dietary intake was assessed by using a 24-h diet recall and was calculated as percentages of energy. Results: Participants were followed for a mean (±SD) of 7.2 ± 2.3 y. During follow-up, 436 incident CHD cases (298 nonfatal CHD and 138 fatal CHD events) were ascertained. Participants aged 47-59 y in the highest quartile of intake of total fat, saturated fatty acids, or monounsaturated fatty acids had higher CHD mortality than did those in the lowest quartile [hazard ratio (95% CI): 3.57 (1.21, 10.49), 5.17 (1.64, 16.36), and 3.43 (1.17, 10.04), respectively] after confounders were controlled for. These associations were not observed for those aged 60-79 y. Conclusions: Total fat, saturated fatty acid, and monounsaturated fatty acid intake were strong predictors of CHD mortality in American Indians aged 47-59 y, independent of other established CHD risk factors. It may be prudent for American Indians to reduce their fat intake early in life to reduce the risk of dying from CHD.
AB - Background: The results of previous studies on the association between dietary fat intake and coronary heart disease (CHD) incidence are inconsistent. Objective: The aim of this study was to examine the association between dietary fat intake and CHD incidence in American Indians in the Strong Heart Study. Design: A total of 2938 participants aged 47-79 y and free of CHD at the second examination (1993-1995) were examined and followed for CHD, nonfatal CHD, and fatal CHD events to 31 December 2002. Dietary intake was assessed by using a 24-h diet recall and was calculated as percentages of energy. Results: Participants were followed for a mean (±SD) of 7.2 ± 2.3 y. During follow-up, 436 incident CHD cases (298 nonfatal CHD and 138 fatal CHD events) were ascertained. Participants aged 47-59 y in the highest quartile of intake of total fat, saturated fatty acids, or monounsaturated fatty acids had higher CHD mortality than did those in the lowest quartile [hazard ratio (95% CI): 3.57 (1.21, 10.49), 5.17 (1.64, 16.36), and 3.43 (1.17, 10.04), respectively] after confounders were controlled for. These associations were not observed for those aged 60-79 y. Conclusions: Total fat, saturated fatty acid, and monounsaturated fatty acid intake were strong predictors of CHD mortality in American Indians aged 47-59 y, independent of other established CHD risk factors. It may be prudent for American Indians to reduce their fat intake early in life to reduce the risk of dying from CHD.
KW - American Indians
KW - Cholesterol
KW - Coronary heart disease
KW - Dietary fat intake
KW - Fatty acids
KW - Mortality
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U2 - 10.1093/ajcn/84.4.894
DO - 10.1093/ajcn/84.4.894
M3 - Article
C2 - 17023718
AN - SCOPUS:33750623567
SN - 0002-9165
VL - 84
SP - 894
EP - 902
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 4
ER -