Abstract
The aryl hydrocarbon receptor (AhR) is a ligand-Activated basic-helix-loop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement ofhealth-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.
Original language | English (US) |
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Pages (from-to) | 455-478 |
Number of pages | 24 |
Journal | Annual Review of Nutrition |
Volume | 41 |
DOIs | |
State | Published - Oct 11 2021 |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics