Diagnostic Devices for Circulating Biomarkers Detection and Quantification

Chiara Bedin, Sara Crotti, Ennio Tasciotti, Marco Agostini

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotechnology. Nanomaterials-based systems have significant advantages over current conventional approaches in terms of simplicity, sensitivity, specificity, and rapidity. In this review, we describe the most interesting nanotechnological devices/approaches proposed for circulating biomarkers detection in oncology. In particular, new applicable nanobiosensors for nucleic acids and proteins identification are discussed and classified into four most interesting nanotech-nologies: bio-barcodes, quantum dots, metal nanoparticles and carbon-based nanosensors. Their versatility has been demonstrated in different applications aiming to detect and quantify cancer biomarkers in real biological samples, in order to show how these methods can lead, in the future, to the development of devices for routine clinical application.

Original languageEnglish (US)
Pages (from-to)4304-4327
Number of pages24
JournalCurrent Medicinal Chemistry
Volume25
Issue number34
Early online dateNov 16 2017
DOIs
StatePublished - Jan 1 2018

Keywords

  • Blood
  • Cancer
  • Circulating biomarkers
  • Nanotechnology
  • Plasma
  • Serum

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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