TY - JOUR
T1 - Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas
AU - Hu, Honghua
AU - Shklovskaya, Elena
AU - Deva, Anand
AU - Xu, Haiying
AU - Fan, Kelly
AU - Brosamer, Kristen
AU - Willson, Richard
AU - Khan, Imran
AU - Sinha, Mithun
AU - Kadin, Marshall E.
N1 - Funding Information:
Grant IIT‐2018‐10408 from Allergan, a subdivision of AbbVie and a grant from the Aesthetic Surgery Research and Education Foundation (ASERF), both to MEK.
© 2023 Wiley Periodicals LLC.
PY - 2023/11
Y1 - 2023/11
N2 - More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.
AB - More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.
UR - http://www.scopus.com/inward/record.url?scp=85169165767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85169165767&partnerID=8YFLogxK
U2 - 10.1002/ajh.27055
DO - 10.1002/ajh.27055
M3 - Article
C2 - 37646570
AN - SCOPUS:85169165767
SN - 0361-8609
VL - 98
SP - E312-E314
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 11
ER -