Diabetes mellitus and experimental vein graft structure and function

Mark G. Davies, Jay H. Kim, Michael L. Klyachkin, Lizzie Barber, Helge Dalen, Einar Svendsen, Cully C. Carson, Per Otto Hagen

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Purpose: Diabetes mellitus is a known risk factor for accelerated atherosclerosis and for postangioplasty restenosis. Methods: This study examines the effect of chronic, uncontrolled, alloxan-induced diabetes on the structure and vasomotor function of vein bypass grafts in 20 male New Zealand white rabbits with diabetes and in 10 controls. After 8 weeks of diabetes, a common carotid vein bypass graft was performed. Four weeks after operation, vein grafts and contralateral jugular veins were harvested. Results: Diabetes induced a twofold increase in the vein graft intimal thickness compared with control. There was no change in medial thickness. Electron microscopy of the vein grafts in diabetes revealed intercellular gaps in the endothelium lining and abnormal endothelial cell junctions compared with controls. Diabetes significantly increased the maximal contractions generated in vein grafts to all contractile agonists tested without any change in sensitivity. Conclusions: This study demonstrates that diabetes alters endothelial cell structure and increases the development of intimal hyperplasia with increased maximal contractility in vein grafts and therefore suggests that the vein grafts in diabetes are more susceptible to early stenosis.

Original languageEnglish (US)
Pages (from-to)1031-1043
Number of pages13
JournalJournal of Vascular Surgery
Issue number6
StatePublished - 1994

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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