Developments in the treatment of candidiasis: More choices and new challenges

George Aperis, Nikolaos Myriounis, Elias K. Spanakis, Eleftherios Mylonakis

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The incidence of oesophageal candidiasis, candidaemia and disseminated candidiasis has increased dramatically. In addition to the amphotericin B formulations and fluconazole, the echinocandins anidulafungin, caspofungin and micafungin and the newer triazoles posaconazole and voriconazole are in the last stages of development and are becoming available for the management of candidiasis. This review presents these new agents and addresses their role in the treatment of candidiasis. All new antifungal agents exhibit potent activity against Candida spp. and echinocandins are fungicidal against most Candida spp. but appear to be less potent against certain species, such as Candida parapsilosis and C. guilliermondii. Systemic antifungal therapy can now be individualised based on the severity of the infection, comorbid conditions and the Candida spp. causing the infection. Studies are needed to investigate the possible development of resistance and the efficacy of these antifungal agents against the more resistant Candida spp.

Original languageEnglish (US)
Pages (from-to)1319-1336
Number of pages18
JournalExpert Opinion on Investigational Drugs
Issue number11
StatePublished - Nov 2006


  • Anidulafungin
  • BAL4815
  • Candida
  • Candidaemia
  • Candidiasis
  • Caspofungin
  • FK463
  • L-743872
  • LY303366
  • Micafungin
  • MK-0991
  • Posaconazole
  • SCH56592
  • UK-109496
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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