TY - JOUR
T1 - Development of Sr and CO3 co-substituted hydroxyapatites for biomedical applications
AU - Landi, Elena
AU - Sprio, Simone
AU - Sandri, Monica
AU - Celotti, Giancarlo
AU - Tampieri, Anna
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2008/5
Y1 - 2008/5
N2 - Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks' balanced solution of SrCHA granules (400-600 μm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogous carbonate free granulate. SrCHA porous bodies with interconnected micro- and macro-porosity, which mimic the morphology of spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the SrCHA powder and controlled sintering. SrCHA porous scaffolds sintered at 850 °C, in flowing CO2 atmosphere, showed satisfying compressive strength (4.58 ± 0.75 MPa) for a porosity value of 45 vol.% and retained the desired ionic substitutions (Sr/Ca = 0.11 and CO3 = 6.8 wt.%). The possibility of widely modulating, by acting on the chemical-physical-geometrical features of the material, the prolonged in situ release of therapeutic Sr, together with the fundamental (Ca, PO4) and main substituting (CO3) ions that constitute the bone mineral phase, makes the use of SrCHA as resorbable bone filler or bone substitute scaffolds promising, especially when pathologies related with Sr deficiency are present. In vitro and in vivo tests are in progress.
AB - Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks' balanced solution of SrCHA granules (400-600 μm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogous carbonate free granulate. SrCHA porous bodies with interconnected micro- and macro-porosity, which mimic the morphology of spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the SrCHA powder and controlled sintering. SrCHA porous scaffolds sintered at 850 °C, in flowing CO2 atmosphere, showed satisfying compressive strength (4.58 ± 0.75 MPa) for a porosity value of 45 vol.% and retained the desired ionic substitutions (Sr/Ca = 0.11 and CO3 = 6.8 wt.%). The possibility of widely modulating, by acting on the chemical-physical-geometrical features of the material, the prolonged in situ release of therapeutic Sr, together with the fundamental (Ca, PO4) and main substituting (CO3) ions that constitute the bone mineral phase, makes the use of SrCHA as resorbable bone filler or bone substitute scaffolds promising, especially when pathologies related with Sr deficiency are present. In vitro and in vivo tests are in progress.
KW - Biomedical applications
KW - Mechanical properties
KW - Porous scaffold
KW - Solubility test
KW - Strontium carbonate apatite
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U2 - 10.1016/j.actbio.2007.10.010
DO - 10.1016/j.actbio.2007.10.010
M3 - Article
C2 - 18063430
AN - SCOPUS:41549085519
SN - 1742-7061
VL - 4
SP - 656
EP - 663
JO - Acta Biomaterialia
JF - Acta Biomaterialia
IS - 3
ER -