Development of Sr and CO3 co-substituted hydroxyapatites for biomedical applications

Elena Landi, Simone Sprio, Monica Sandri, Giancarlo Celotti, Anna Tampieri

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks' balanced solution of SrCHA granules (400-600 μm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogous carbonate free granulate. SrCHA porous bodies with interconnected micro- and macro-porosity, which mimic the morphology of spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the SrCHA powder and controlled sintering. SrCHA porous scaffolds sintered at 850 °C, in flowing CO2 atmosphere, showed satisfying compressive strength (4.58 ± 0.75 MPa) for a porosity value of 45 vol.% and retained the desired ionic substitutions (Sr/Ca = 0.11 and CO3 = 6.8 wt.%). The possibility of widely modulating, by acting on the chemical-physical-geometrical features of the material, the prolonged in situ release of therapeutic Sr, together with the fundamental (Ca, PO4) and main substituting (CO3) ions that constitute the bone mineral phase, makes the use of SrCHA as resorbable bone filler or bone substitute scaffolds promising, especially when pathologies related with Sr deficiency are present. In vitro and in vivo tests are in progress.

Original languageEnglish (US)
Pages (from-to)656-663
Number of pages8
JournalActa Biomaterialia
Issue number3
StatePublished - May 2008


  • Biomedical applications
  • Mechanical properties
  • Porous scaffold
  • Solubility test
  • Strontium carbonate apatite

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology


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