@article{cd5e82c2d774409b9b7ae5c81a3b29d4,
title = " Development of photoactive Sweet-C 60 for pancreatic cancer stellate cell therapy ",
abstract = " Aim: Glycoconjugated C 60 derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the case of pancreatic adenocarcinoma and its dense stroma, which is known to be driven by a subset of pancreatic stellate cells. Materials & methods: Herein, we describe the synthesis and biological characterization of a hexakis-glucosamine C 60 derivative (termed 'Sweet-C 60 '). Results: Synthesized fullerene derivative predominantly accumulates in the nucleus of pancreatic stellate cells; is inherently nontoxic up to concentrations of 1 mg/ml; and is photoactive when illuminated with blue and green light, allowing its use as a photodynamic therapy agent. Conclusion: Obtained glycoconjugated nanoplatform is a promising nanotherapeutic for pancreatic cancer. ",
keywords = "[60]fullerene, fullerene antibody, glycoconjugates, pancreatic stellate cells, photodynamic therapy",
author = "Maciej Serda and Ware, {Matthew J.} and Newton, {Jared M.} and Sanchit Sachdeva and Martyna Krzykawska-Serda and Lam Nguyen and Justin Law and Anderson, {Andrew O.} and Curley, {Steven A.} and Wilson, {Lon J.} and Corr, {Stuart J.}",
note = "Funding Information: M Serda, JM Newton, MJ Ware, S Sachdeva, M Krzykawska-Serda, J Law, L Nguyen, SA Curley and SJ Corr acknowledge the funding of Kanzius Foundation and NIH U54CA143837. LJ Wilson also thanks the Welch Foundation (grant number C-0627) for support. Additionally, M Serda thanks National Science Center (Poland) for the support (grant number UMO-2016/23/D/NZ7/00912). MJ Ware and SJ Corr acknowledge the support of St Luke{\textquoteright}s Foundation Philip Salem Award. JM Newton acknowledges financial support from the NIGMS T32 predoctoral training (grant number T32GM088129) and NIDCR F31 NRSA training grant (grant number F31DE026682) both of the NIH. This project was supported by the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the NIH (grant numbers NIAID P30AI036211, NCI P30CA125123 and NCRR S10RR024574) and the assistance of JM Sederstrom. This content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",
year = "2018",
month = dec,
day = "1",
doi = "10.2217/nnm-2018-0239",
language = "English (US)",
volume = "13",
pages = "2981--2993",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "23",
}