Development of multisubstituted apatites for bone reconstruction

Elena Landi, Simone Sprio, Monica Sandri, Anna Tampieri, Luca Bertinetti, Gianmario Martra

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hydroxyapatite powders characterized by substitutions of Mg2+, SiO4 4-, CO3 2- ions in biological like amounts, in the crystallographic site of calcium and phosphates, ions in biological like amounts, in the crystallographic site of calcium and phosphorus, were successfully prepared by synthesis in aqueous medium. The chemico-physical properties of the powders were investigated through several analytical techniques, among them: XRD, FTIR, TG-DTA, ICP-OES, HR-TEM. The entering of silicon in the HA structure progressively reduces its crystallinity, as also carbonate ions do. Silicate and carbonate ions can enter simultaneously into the HA structure, in biological-like amounts, although they compete for the occupation of the phosphate site. Solubility tests, carried out at physiological conditions, reveal an increased calcium release in the HA powders containing silicon compared to the silicon-free HA.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
StatePublished - 2008


  • Carbonate
  • Magnesium
  • Non stoichiometric hydroxyapatite
  • Silicon
  • Solubility

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)


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