Development of multiple-layer polymeric particles for targeted and controlled drug delivery

Bhanuprasanth Koppolu, Maham Rahimi, Sivaniarvindpriya Nattama, Aniket Wadajkar, Kytai Truong Nguyen

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The purpose of this work was to develop multilayered particles consisting of a magnetic core and two encompassing shells made up of poly(N-isopropylacrylamide) (PNIPAAm) and poly(d,l-lactide-co-glycolide) (PLGA) for targeted and controlled drug delivery. Transmission electron microscopy confirmed that multilayered particles were obtained with PNIPAAm magnetic nanoparticles embedded within the PLGA shell. Factorial analysis studies also showed that the particle size was inversely proportional to the surfactant concentration and sonication power and directly proportional to the PLGA concentration. Drug-release results demonstrated that these multilayer particles produced an initial burst release and a subsequent sustained release of both bovine serum albumin (BSA) and curcumin loaded into the core and shell of the particle, respectively. BSA release was also affected by changes in temperature. In conclusion, our results indicate that the multilayered magnetic particles could be synthesized and used for targeted and controlled delivery of multiple drugs with different release mechanisms. From the Clinical Editor: Authors demonstrate the synthesis of multilayered particles consisting of a magnetic core and two encompassing shells made up of poly (N-isopropylacrylamide) (PNIPAAm) and poly(D, L-lactide-co-glycolide) (PLGA) for targeted and controlled drug delivery. The presented results indicate successful synthesis and application for targeted and controlled delivery of multiple drugs with different release mechanisms.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume6
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • Biodegradable
  • Dual drug release
  • Multilayered particles
  • Temperature sensitive

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Development of multiple-layer polymeric particles for targeted and controlled drug delivery'. Together they form a unique fingerprint.

Cite this