Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system

Elisabetta Campodoni, Alessio Adamiano, Samuele M. Dozio, Silvia Panseri, Monica Montesi, Simone Sprio, Anna Tampieri, Monica Sandri

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aim: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling. Materials & methods: Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique. Results: The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions. Conclusion: The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.

Original languageEnglish (US)
Pages (from-to)2119-2130
Number of pages12
JournalNanomedicine
Volume11
Issue number16
DOIs
StatePublished - Aug 1 2016

Keywords

  • drug delivery
  • hybrid nanoparticles
  • iron-doped apatite
  • nanotechnology
  • regenerative medicine
  • superparamagnetism

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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