Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system

Elisabetta Campodoni; Alessio Adamiano; Samuele M. Dozio; Silvia Panseri; Monica Montesi; Simone Sprio; Anna Tampieri; Monica Sandri

doi:10.2217/nnm-2016-0101

Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system

Elisabetta Campodoni, Alessio Adamiano, Samuele M. Dozio, Silvia Panseri, Monica Montesi, Simone Sprio, Anna Tampieri, Monica Sandri

Houston Methodist

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Aim: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling. Materials & methods: Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique. Results: The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions. Conclusion: The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.

Original language	English (US)
Pages (from-to)	2119-2130
Number of pages	12
Journal	Nanomedicine
Volume	11
Issue number	16
DOIs	https://doi.org/10.2217/nnm-2016-0101
State	Published - Aug 2016

Keywords

drug delivery
hybrid nanoparticles
iron-doped apatite
nanotechnology
regenerative medicine
superparamagnetism

ASJC Scopus subject areas

Bioengineering
Materials Science(all)
Biomedical Engineering
Medicine (miscellaneous)

Access to Document

10.2217/nnm-2016-0101

Cite this

@article{5f7c79edd41e47a399a4865a9efabdf5,

title = "Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system",

abstract = "Aim: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling. Materials & methods: Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique. Results: The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions. Conclusion: The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.",

keywords = "drug delivery, hybrid nanoparticles, iron-doped apatite, nanotechnology, regenerative medicine, superparamagnetism",

author = "Elisabetta Campodoni and Alessio Adamiano and Dozio, {Samuele M.} and Silvia Panseri and Monica Montesi and Simone Sprio and Anna Tampieri and Monica Sandri",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = aug,

doi = "10.2217/nnm-2016-0101",

language = "English (US)",

volume = "11",

pages = "2119--2130",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "16",

}

TY - JOUR

T1 - Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system

AU - Campodoni, Elisabetta

AU - Adamiano, Alessio

AU - Dozio, Samuele M.

AU - Panseri, Silvia

AU - Montesi, Monica

AU - Sprio, Simone

AU - Tampieri, Anna

AU - Sandri, Monica

PY - 2016/8

Y1 - 2016/8

N2 - Aim: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling. Materials & methods: Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique. Results: The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions. Conclusion: The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.

AB - Aim: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling. Materials & methods: Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique. Results: The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions. Conclusion: The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.

KW - drug delivery

KW - hybrid nanoparticles

KW - iron-doped apatite

KW - nanotechnology

KW - regenerative medicine

KW - superparamagnetism

UR - http://www.scopus.com/inward/record.url?scp=84982182596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982182596&partnerID=8YFLogxK

U2 - 10.2217/nnm-2016-0101

DO - 10.2217/nnm-2016-0101

M3 - Article

C2 - 27463861

AN - SCOPUS:84982182596

SN - 1743-5889

VL - 11

SP - 2119

EP - 2130

JO - Nanomedicine

JF - Nanomedicine

IS - 16

ER -

Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this