Development of clear cell adenocarcinoma in des-exposed offspring under observation

Raymond H. Kaufman, Matti O. Korhonen, Thomas Strama, Ervin Adam, Alan L. Kaplan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in utero to diethylstilbestrol are reported. One patient, aged 23, had been followed for 2 years before carcinoma was diagnosed; the second patient, aged 22, had been seen on a regular basis for 5 years, 8 months. In both instances, suspicion of the presence of carcinoma was aroused by the palpation of a small nodule in the vaginal fornix. Hysterosalpinography was performed on both patients and, in 1 instance, an abnormal x-ray film was reflected by the gross appearance of the uterine cavity found in the surgical specimen.

Original languageEnglish (US)
Pages (from-to)68S-72S
JournalObstetrics and Gynecology
Issue number6
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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