Development of CD8α/α and CD8α/β T cells in major histocompatibility complex class I-deficient mice

Das Gobardhan, Charles A. Janeway

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Peripheral CD8+ T cells mainly use CDSα/β, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins Kb and Db in H-2b mice. In this report, we have shown that the development of CD8α/β TCR-α/β cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I Kb and Db proteins. In contrast, TCR-α/β CD8α/α cells are found mainly in iIELs, and their numbers are unaffected in KbDb double knockout mice. Most of the TCR-γ/γ cells in the iIELs also bear CD8α/α, and they are also unaffected in KbDb -/- mice. In β2-microglobulin (β2m)-deficient mice, all of the TCR-α/β CD8α/α and CD8α/β T cells disappear, but TCR- γ/δ cells are unaffected by the absence of β2m.

Original languageEnglish (US)
Pages (from-to)881-884
Number of pages4
JournalJournal of Experimental Medicine
Volume190
Issue number6
DOIs
StatePublished - Sep 20 1999

Keywords

  • CD8α/α T cells
  • CD8α/β T cells
  • KD-deficient mice
  • Major histocompatibility complex class I
  • β2m-deficient mice

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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