Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ

Joseph D. Butner, Vittorio Cristini, Zhihui Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Ductal carcinoma in situ (DCIS) is the most commonly diagnosed form of non-invasive breast cancer, constituting 20% of all new breast cancer cases in the United States. Although non-invasive, DCIS is usually treated surgically through resection. Interestingly, long-term survival studies have shown that patient survival rates are not significantly impacted by the type or resection, indicating that increased breast conservation through minimized surgical resection may indeed be possible. This requires a greater understanding of disease development, so that clinicians may more accurately determine surgical margins which minimize patient impact while maintaining survival rates. To this end, we have developed a three-dimensional, lattice-free multiscale agent based model of DCIS designed to help quantify ductal invasion rates, in order to allow clinicians to better estimate disease age and extent of invasion, and to predict surgical margins based on parameters obtainable from non-invasive testing (i.e., mammography). Here, we present the model development to date, and discuss some preliminary results.

Original languageEnglish (US)
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages86-89
Number of pages4
ISBN (Electronic)9781509028092
DOIs
StatePublished - Sep 13 2017
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: Jul 11 2017Jul 15 2017

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period7/11/177/15/17

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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