TY - JOUR
T1 - Development and evaluation of the liver disease quality of life instrument in persons with advanced, chronic liver disease - The LDQOL 1.0
AU - Gralnek, Ian M.
AU - Hays, Ron D.
AU - Kilbourne, Amy
AU - Rosen, Hugo R.
AU - Keeffe, Emmet B.
AU - Artinian, Lucy
AU - Kim, Sehyun
AU - Lazarovici, Dana
AU - Jensen, Dennis M.
AU - Busuttil, Ronald W.
AU - Martin, Paul
N1 - Funding Information:
Supported by a Veterans Affairs Health Services Research & Development Research Career Development Award (to I.M.G.), and American Society for Gastrointestinal Endoscopy/American Digestive Health Foundation Endoscopic Outcomes and Effectiveness Award (to I.M.G.), and by a grant from Amgen, Thousand Oaks, CA (to R.D.H.). We wish to thank all of the nurses and transplant coordinators at the participating centers without whose help this study would not have been possible.
PY - 2000
Y1 - 2000
N2 - OBJECTIVES: Assessment of health-related quality of life (HRQOL) outcomes in studies of liver disease and liver transplantation is necessary. Reliable and valid disease-targeted HRQOL measures are thus needed. The objective of this study was to develop a reliable and valid self-report HRQOL instrument for ambulatory adults with chronic liver disease. METHODS: The Liver Disease Quality of Life instrument, LDQOL 1.0 (an HRQOL measure that uses the SF-36 as a generic core and 12 disease-targeted multi-item scales) was administered in a multicenter, cross-sectional field test to 221 ambulatory adults with advanced, chronic liver disease referred for primary liver transplantation evaluation. Disease-targeted scales included liver disease-related symptoms, liver disease-related effects on activities of daily living, concentration, memory, sexual functioning, sexual problems, sleep, loneliness, hopelessness, quality of social interaction, health distress, and self-perceived stigma of liver disease. We estimated the internal consistency reliability (Cronbach's α) for multi-item scales and construct validity. RESULTS: Internal consistency reliability coefficients were excellent, ranging from 0.62 to 0.95, with 19 of 20 scales >0.70. Multitrait scaling analysis provided strong support for item discrimination across scales, and exploratory factor analysis demonstrated distinguishable physical, mental, and social health dimensions. Significant associations were found between worse HRQOL and worse Child-Pugh class, worse self-rated liver disease severity, and increased number of disability days. CONCLUSIONS: The results of this multicenter field test provide support for the reliability and validity of the LDQOL 1.0 as an HRQOL outcome measure for individuals with chronic liver disease. (C) 2000 by Am. Coll. of Gastroenterology.
AB - OBJECTIVES: Assessment of health-related quality of life (HRQOL) outcomes in studies of liver disease and liver transplantation is necessary. Reliable and valid disease-targeted HRQOL measures are thus needed. The objective of this study was to develop a reliable and valid self-report HRQOL instrument for ambulatory adults with chronic liver disease. METHODS: The Liver Disease Quality of Life instrument, LDQOL 1.0 (an HRQOL measure that uses the SF-36 as a generic core and 12 disease-targeted multi-item scales) was administered in a multicenter, cross-sectional field test to 221 ambulatory adults with advanced, chronic liver disease referred for primary liver transplantation evaluation. Disease-targeted scales included liver disease-related symptoms, liver disease-related effects on activities of daily living, concentration, memory, sexual functioning, sexual problems, sleep, loneliness, hopelessness, quality of social interaction, health distress, and self-perceived stigma of liver disease. We estimated the internal consistency reliability (Cronbach's α) for multi-item scales and construct validity. RESULTS: Internal consistency reliability coefficients were excellent, ranging from 0.62 to 0.95, with 19 of 20 scales >0.70. Multitrait scaling analysis provided strong support for item discrimination across scales, and exploratory factor analysis demonstrated distinguishable physical, mental, and social health dimensions. Significant associations were found between worse HRQOL and worse Child-Pugh class, worse self-rated liver disease severity, and increased number of disability days. CONCLUSIONS: The results of this multicenter field test provide support for the reliability and validity of the LDQOL 1.0 as an HRQOL outcome measure for individuals with chronic liver disease. (C) 2000 by Am. Coll. of Gastroenterology.
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U2 - 10.1016/S0002-9270(00)02168-7
DO - 10.1016/S0002-9270(00)02168-7
M3 - Article
C2 - 11151892
AN - SCOPUS:0033638243
SN - 0002-9270
VL - 95
SP - 3552
EP - 3565
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 12
ER -