Development and applications of a molecular genetic linkage map of the mouse genome

Research output: Contribution to journalReview article

472 Scopus citations

Abstract

Interspecific mouse backcrosses provide almost limitless genetic variation for gene mapping. We have used interspecific backcrosses to develop the first comprehensive molecular genetic linkage map of the mouse genome. More than 600 loci have been positioned on the map; the current average map resolution is less than 3 cM. Since all loci were mapped using a single backcross panel, gene order can be determined unambiguously. With this level of resolution, it is now possible to position any new locus on the linkage map with virtually 100% certainty. In this article, we review how interspecific linkage maps are constructed, the salient features of our linkage map, and some of the many applications of interspecific linkage maps, in general, for future research.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalTrends in Genetics
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Genetics

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