Developing therapies to treat hepatitis C infection in post-liver transplant recipients

Thomas R. McCarty, Joseph K. Lim

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Introduction: Currently, hepatitis C virus (HCV) infection remains the most common indication for liver transplant in the United States (US) with almost universal HCV recurrence in the post-liver transplant setting. Previous interferon (IFN)-related efficacy and tolerability concerns about worsening liver function have limited treatment options for many patients with HCV-associated decompensated liver disease and post-liver transplant recipients. However, the last decade has seen a seen a radical shift in the management of HCV with multiple direct-acting antiviral (DAA) treatments that provide more effective, all-oral, IFN-free alternatives. Areas covered: This review will serve to highlight the various pharmacotherapies available to clinicians for patients with HCV recurrence post-liver transplant. A brief history of prior regimens is provided with evidence for newer treatments presented. Also detailed are updated guidelines from societal organizations. Finally, timing of HCV treatment is discussed as the decision to treat patients in a pre or post-liver transplant setting remains challenging. Expert opinion: While there are many potential available therapies for HCV recurrence in the post-liver transplant setting, daclatasvir/sofosbuvir and ledipasvir/sofosbuvir have been the most extensively studied. Newer, pangenotypic generation drugs require more evidence before routine utilization in post-liver transplant recipients.

Original languageEnglish (US)
Pages (from-to)165-174
Number of pages10
JournalExpert Opinion on Pharmacotherapy
Issue number2
StatePublished - Jan 22 2017


  • Cirrhosis
  • direct-acting antiviral (DAA) therapy
  • hepatitis C virus (HCV)
  • liver transplant

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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