Developing keratin sponges with tunable morphologies and controlled antioxidant properties induced by doping with polydopamine (PDA) nanoparticles

T. Posati, G. Sotgiu, G. Varchi, C. Ferroni, R. Zamboni, F. Corticelli, D. Puglia, L. Torre, A. Terenzi, A. Aluigi

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

This work investigates the preparation of wool keratin sponges by freeze-drying procedure starting form keratin aqueous solutions. The study highlights the correlations between process parameters (protein concentration and freezing rate) and the chemical-physical properties of the final sponges. In particular, as the keratin concentration increases from 1 to 20% wt, the mean pore size and the porosity decrease from 62 to 37 μm and from 94 to 50% respectively, while the chemical stability in physiological conditions increases, as well as the thermal stability and the elastic modulus. On the other hand, the increase of the freezing rate affects the design of sponges that appear as stacked leaflets structures with oriented pores. Moreover, in order to confer to keratin sponges antioxidant properties, polydopamine (PDA) nanoparticles were used as fillers. To this end, PDA nanoparticles of about 130 nm were successfully dispersed in the sponges, bestowing time-dependent anti-oxidant properties on the scaffolds, with no significant modification of sponges morphological structure as well as reduction of the thermal stability and mechanical behaviour.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
JournalMaterials and Design
Volume110
DOIs
StatePublished - Nov 15 2016

Keywords

  • Keratin
  • Polydopamine
  • Pore structure
  • Scavenging activity
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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