Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

Carly S Levin; Sandra Whaley Bishnoi; Nathaniel K Grady; Naomi J. Halas

doi:10.1021/ac060041z

Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

Carly S Levin, Sandra Whaley Bishnoi, Nathaniel K Grady, Naomi J. Halas

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact "brush" rather than an extended "mushroom" configuration on nanoshell surfaces.

Original language	English (US)
Pages (from-to)	3277-81
Number of pages	5
Journal	Analytical Chemistry
Volume	78
Issue number	10
DOIs	https://doi.org/10.1021/ac060041z
State	Published - May 15 2006

Keywords

Gold
Molecular Conformation
Nanostructures
Polyethylene Glycols
Spectrum Analysis, Raman
Sulfhydryl Compounds
Surface Properties
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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10.1021/ac060041z

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title = "Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay",

abstract = "The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact {"}brush{"} rather than an extended {"}mushroom{"} configuration on nanoshell surfaces.",

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author = "Levin, {Carly S} and Bishnoi, {Sandra Whaley} and Grady, {Nathaniel K} and Halas, {Naomi J.}",

year = "2006",

month = may,

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doi = "10.1021/ac060041z",

language = "English (US)",

volume = "78",

pages = "3277--81",

journal = "Analytical Chemistry",

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publisher = "American Chemical Society",

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T1 - Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

AU - Levin, Carly S

AU - Bishnoi, Sandra Whaley

AU - Grady, Nathaniel K

AU - Halas, Naomi J.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact "brush" rather than an extended "mushroom" configuration on nanoshell surfaces.

AB - The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact "brush" rather than an extended "mushroom" configuration on nanoshell surfaces.

KW - Gold

KW - Molecular Conformation

KW - Nanostructures

KW - Polyethylene Glycols

KW - Spectrum Analysis, Raman

KW - Sulfhydryl Compounds

KW - Surface Properties

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

U2 - 10.1021/ac060041z

DO - 10.1021/ac060041z

M3 - Article

C2 - 16689527

SN - 0003-2700

VL - 78

SP - 3277

EP - 3281

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 10

ER -

Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

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Keywords

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