Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

Carly S Levin, Sandra Whaley Bishnoi, Nathaniel K Grady, Naomi J. Halas

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact "brush" rather than an extended "mushroom" configuration on nanoshell surfaces.

Original languageEnglish (US)
Pages (from-to)3277-81
Number of pages5
JournalAnalytical Chemistry
Volume78
Issue number10
DOIs
StatePublished - May 15 2006

Keywords

  • Gold
  • Molecular Conformation
  • Nanostructures
  • Polyethylene Glycols
  • Spectrum Analysis, Raman
  • Sulfhydryl Compounds
  • Surface Properties
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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