TY - JOUR
T1 - Determination of wall shear stress in the aorta with the use of MR phase velocity mapping
AU - Osinnski, John N.
AU - Ku, David N.
AU - Mukundan, Srinivasan
AU - Loth, Francis
AU - Pettigrew, Roderic I.
PY - 1995
Y1 - 1995
N2 - MR phase velocity mapping was used to calculate wall shear stress (WSS) in the suprarenal and infrarenal abdominal aorta, two sites with very different proclivities for development of atherosclerosis. For the eight subjects studied, the average value of the mean (tune averaged over the cardiac cycle) WSS in the suprarenal aorta was 10.4 dynes/cm2 at the posterior wall and 8.6 at the anterior wall. In the infrarenal aorta, WSS values were 4.7 at the posterior wall and 6.1 at the anterior wall. Peak WSS over the cardiac cycle was 48 and 54 at the anterior and posterior walls of the suprarenal aorta, respectively, and 33 and 30 at the anterior and posterior walls of the infrarenal aorta, respectively. Wide variation was found in both mean and peak WSS values among subjects. However, for 28 of 32 locations examined, mean and peak WSS were ingher in the suprarenal aorta than in the infrarenal aorta. Because atherosclerosis is more likely to form in the infrarenal aorta than in the suprarenal aorta, tins study supports the hypothesis that low WSS is a localizing factor for atherosclerosis, and ingh WSS may act as a deterrent against formation of atherosclerosis.
AB - MR phase velocity mapping was used to calculate wall shear stress (WSS) in the suprarenal and infrarenal abdominal aorta, two sites with very different proclivities for development of atherosclerosis. For the eight subjects studied, the average value of the mean (tune averaged over the cardiac cycle) WSS in the suprarenal aorta was 10.4 dynes/cm2 at the posterior wall and 8.6 at the anterior wall. In the infrarenal aorta, WSS values were 4.7 at the posterior wall and 6.1 at the anterior wall. Peak WSS over the cardiac cycle was 48 and 54 at the anterior and posterior walls of the suprarenal aorta, respectively, and 33 and 30 at the anterior and posterior walls of the infrarenal aorta, respectively. Wide variation was found in both mean and peak WSS values among subjects. However, for 28 of 32 locations examined, mean and peak WSS were ingher in the suprarenal aorta than in the infrarenal aorta. Because atherosclerosis is more likely to form in the infrarenal aorta than in the suprarenal aorta, tins study supports the hypothesis that low WSS is a localizing factor for atherosclerosis, and ingh WSS may act as a deterrent against formation of atherosclerosis.
KW - Atherosclerosis
KW - Flow
KW - MR Imaging
KW - Velocity
KW - Wall shear stress
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U2 - 10.1002/jmri.1880050605
DO - 10.1002/jmri.1880050605
M3 - Article
C2 - 8748480
AN - SCOPUS:0029399233
VL - 5
SP - 640
EP - 647
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 6
ER -