Determination of myocardial viability with ECG-gated fluorodeoxyglucose F-18 positron emission tomography

Hee Seung Bom, John P. Vansant, Roderic I. Pettigrew, C. David Cooke, John R. Votaw, Ernest V. Garcia

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: We hypothesize that ECG-gated positron emission tomography (PET) using Fluorodeoxyglucose F-18 (FDG) alone can determine myocardial viability by identifying dysfunctional myocardium with preserved glucose metabolism. We compared the contraction-metabolism pattern of gated FDG PET with the perfusion-metabolism pattern of conventional PET using N-13 ammonia (NH3) as a perfusion agent and FDG as a glucose metabolism agent in 21 consecutive patients with chronic coronary artery disease with left ventricular dysfunction (mean ejection fraction 23.6 ± 7.7%). Methods: The left ventricle was divided into 17 segments. Uptakes of NH3 and FDG were scored from absent (0) to normal (4), and wall motion was scored from dyskinesia (-1) to normal (3). Scores were determined by the visual interpretation of the majority of 3 blinded expert readers. Viable myocardium was defined by normal or mildly reduced uptakes of both NH3 and FDG, perfusion-metabolism mismatch on NH3-FDG PET, or normal to mildly reduced uptake of FDG with regional dysfunction on gated FDG PET. Results: Gated FDG PET identified 184 segments as viable, all of which were determined as viable by NH3-FDG PET. Among 125 segments identified as nonviable by NH3-FDG PET, 76 segments were determined as nonviable by NH3-FDG PET. The results provided a positive and negative predictive value of gated FDG PET for the determination of myocardial viability to be 100% and 60.8%, respectively. Conclusions: Gated FDG PET has a high positive predictive value (100%) for the identification of viable myocardium.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalClinical Positron Imaging (Netherlands)
Volume2
Issue number4
DOIs
StatePublished - 1999

Keywords

  • Gated Fluorodeoxyglucose F-18 (FDG)
  • Myocardial viability
  • Positron Emission Tomography (PET)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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