Determination of Mercury in Fish by Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry

Meng Wang, Yu Zhang, Wei Yue Feng, Ming Guan, Bing Wang, Jue Wen Shi, Mo Tao Zhu, Bai Li, Yu Liang Zhao, Zhi Fang Chai

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A method for mild extraction and subsequent determination of total mercury content in fish by isotope dilution inductively coupled plasma-mass spectrometry (ID-ICP-MS) has been developed. The errors in the measurement of mercury isotope ratio were discussed. The dead time and mass bias induced by the system of ICP-MS were corrected by the use of lead isotopic certified reference material NIST SRM 981. The established method was validated by determining total mercury content in two certified reference materials, IAEA 436 (Tuna) and NRCC DOLT-3 (Dogfish Liver). The results of total mercury presented in IAEA 436 and DOLT-3 were 4.23 ± 0.06 and 3.33 ± 0.05 mg kg-1, respectively, which were in agreement with the certified values. The extraction method was suitable for the determination of mercury by ID-ICP-MS because the memory effect of mercury in the system could be efficiently eliminated.

Original languageEnglish (US)
Pages (from-to)945-948
Number of pages4
JournalChinese Journal of Analytical Chemistry
Issue number7
StatePublished - Jul 2007


  • Inductively coupled plasma-mass spectrometry (ICP-MS)
  • Isotope dilution analysis
  • Mercury

ASJC Scopus subject areas

  • Analytical Chemistry


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