Detection of mild factor VIII deficiency by thrombokinetics

E. A. Natelson, D. Shapiro, D. F. Smith

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The maximal rate of change in optical density (V(max) ΔOD) of plasma clots forming in the activated partial thromboplastin time test (APTT) may be significantly influenced by reductions in factor VIII activity insufficient to also cause a distinctly abnormal timed clotting endpoint. Analysis of relationships between V(max) ΔOD of clotting plasma in the APTT, prothrombin time, and thrombin time tests provides a basis for increasing the screening value of the APTT in suggesting intrinsic system abnormalities. Three illustrative case reports support the added benefit of thrombokinetics in the detection of mild factor VIII deficiency in hemophilia A and in von Willebrand's disease.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalAmerican Journal of Clinical Pathology
Issue number1
StatePublished - 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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