Detection of low‐grade mosaicism in fetal cells isolated from maternal blood

Farideh Z. Bischoff; Dorothy E. Lewis; Joe Leigh Simpson; Dianne D. Nguyen; Jeffrey Scott; Wendy Schober; Sarah Murrell; Sherman Elias

doi:10.1002/pd.1970151218

Detection of low‐grade mosaicism in fetal cells isolated from maternal blood

Farideh Z. Bischoff, Dorothy E. Lewis, Joe Leigh Simpson, Dianne D. Nguyen, Jeffrey Scott, Wendy Schober, Sarah Murrell, Sherman Elias

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

Recovering and analysing fetal erythrocytes from maternal blood is being pursued for non‐invasive prenatal genetic diagnosis. We report the observation of 46, XY/47, XXY mosaicism in fetal cells from a woman whose first‐trimester chorionic villus sampling (CVS) initially showed only 46, XY. Only after exhaustive (500 cells) analysis were four XXY cells found in cultured villi.

Original language	English (US)
Pages (from-to)	1182-1184
Number of pages	3
Journal	Prenatal Diagnosis
Volume	15
Issue number	12
DOIs	https://doi.org/10.1002/pd.1970151218
State	Published - Jan 1 1995

Keywords

FISH
chorionic villus
fetal cells in maternal blood
mosaicism

ASJC Scopus subject areas

Obstetrics and Gynecology
Genetics(clinical)

Access to Document

10.1002/pd.1970151218

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abstract = "Recovering and analysing fetal erythrocytes from maternal blood is being pursued for non‐invasive prenatal genetic diagnosis. We report the observation of 46, XY/47, XXY mosaicism in fetal cells from a woman whose first‐trimester chorionic villus sampling (CVS) initially showed only 46, XY. Only after exhaustive (500 cells) analysis were four XXY cells found in cultured villi.",

keywords = "FISH, chorionic villus, fetal cells in maternal blood, mosaicism",

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T1 - Detection of low‐grade mosaicism in fetal cells isolated from maternal blood

AU - Bischoff, Farideh Z.

AU - Lewis, Dorothy E.

AU - Simpson, Joe Leigh

AU - Nguyen, Dianne D.

AU - Scott, Jeffrey

AU - Schober, Wendy

AU - Murrell, Sarah

AU - Elias, Sherman

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Recovering and analysing fetal erythrocytes from maternal blood is being pursued for non‐invasive prenatal genetic diagnosis. We report the observation of 46, XY/47, XXY mosaicism in fetal cells from a woman whose first‐trimester chorionic villus sampling (CVS) initially showed only 46, XY. Only after exhaustive (500 cells) analysis were four XXY cells found in cultured villi.

AB - Recovering and analysing fetal erythrocytes from maternal blood is being pursued for non‐invasive prenatal genetic diagnosis. We report the observation of 46, XY/47, XXY mosaicism in fetal cells from a woman whose first‐trimester chorionic villus sampling (CVS) initially showed only 46, XY. Only after exhaustive (500 cells) analysis were four XXY cells found in cultured villi.

KW - FISH

KW - chorionic villus

KW - fetal cells in maternal blood

KW - mosaicism

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