Detection of Clostridium difficile toxin: Comparison of enzyme immunoassay results with results obtained by cytotoxicity assay

Daniel M. Musher; Atisha Manhas; Pranav Jain; Franziska Nuila; Amna Waqar; Nancy Logan; Bernard Marino; Edward A. Graviss

doi:10.1128/JCM.00686-07

Detection of Clostridium difficile toxin: Comparison of enzyme immunoassay results with results obtained by cytotoxicity assay

Daniel M. Musher, Atisha Manhas, Pranav Jain, Franziska Nuila, Amna Waqar, Nancy Logan, Bernard Marino, Edward A. Graviss

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Abstract

Several kinds of laboratory techniques are available to detect Clostridium difficile toxin in fecal samples. Because questions have been raised about the reliability of immunoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays (EIAs) and one rapid EIA, which demonstrated relatively good sensitivities and specificities compared to cytotoxicity assay.

Original language	English (US)
Pages (from-to)	2737-2739
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	45
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00686-07
State	Published - Aug 2007

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00686-07

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abstract = "Several kinds of laboratory techniques are available to detect Clostridium difficile toxin in fecal samples. Because questions have been raised about the reliability of immunoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays (EIAs) and one rapid EIA, which demonstrated relatively good sensitivities and specificities compared to cytotoxicity assay.",

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AU - Musher, Daniel M.

AU - Manhas, Atisha

AU - Jain, Pranav

AU - Nuila, Franziska

AU - Waqar, Amna

AU - Logan, Nancy

AU - Marino, Bernard

AU - Graviss, Edward A.

PY - 2007/8

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N2 - Several kinds of laboratory techniques are available to detect Clostridium difficile toxin in fecal samples. Because questions have been raised about the reliability of immunoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays (EIAs) and one rapid EIA, which demonstrated relatively good sensitivities and specificities compared to cytotoxicity assay.

AB - Several kinds of laboratory techniques are available to detect Clostridium difficile toxin in fecal samples. Because questions have been raised about the reliability of immunoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays (EIAs) and one rapid EIA, which demonstrated relatively good sensitivities and specificities compared to cytotoxicity assay.

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Detection of Clostridium difficile toxin: Comparison of enzyme immunoassay results with results obtained by cytotoxicity assay

Abstract

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