TY - JOUR
T1 - Design, Synthesis, and Surface Modification of Materials Based on Transition-Metal Dichalcogenides for Biomedical Applications
AU - Zhu, Shuang
AU - Gong, Linji
AU - Xie, Jiani
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
This work was supported by the National Basic Research Programs of China (Grant Nos. 2016YFA0201600 and 2015CB932104), the National Natural Science Foundation of China (Grant No. 31571015, 11621505, 11435002, and 21320102003), and the Youth Innovation Promotion Association CAS (Grant No. 2013007).
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2017/12/11
Y1 - 2017/12/11
N2 - With the rapid development of nanotechnology, the emerging transition-metal dichalcogenides (TMDCs) have become one of the most promising inorganic nanomaterials for medical applications due to their distinctive structures and properties. TMDCs with different sizes and morphologies exhibit unique structural advantages, as well as versatile properties. However, concerning their practicability for biomedical applications, routes toward their synthesis and chemical/physical functionalization for biosystem applications must be identified. Herein, recent advances in the design, synthesis, and surface modification of TMDC-based nanomaterials specific for biomedical applications are reviewed. First, the basic consideration regarding how to fabricate biocompatible TMDCs efficiently for biomedical use is discussed. Solution-based synthesis methods for 2D TMDCs, as well as TMDC-based nanocomposites are then summarized. In addition, general strategies applied for surface functionalization of TMDCs are also discussed. Finally, current challenges and future perspectives for these promising materials in biosystem applications are outlined.
AB - With the rapid development of nanotechnology, the emerging transition-metal dichalcogenides (TMDCs) have become one of the most promising inorganic nanomaterials for medical applications due to their distinctive structures and properties. TMDCs with different sizes and morphologies exhibit unique structural advantages, as well as versatile properties. However, concerning their practicability for biomedical applications, routes toward their synthesis and chemical/physical functionalization for biosystem applications must be identified. Herein, recent advances in the design, synthesis, and surface modification of TMDC-based nanomaterials specific for biomedical applications are reviewed. First, the basic consideration regarding how to fabricate biocompatible TMDCs efficiently for biomedical use is discussed. Solution-based synthesis methods for 2D TMDCs, as well as TMDC-based nanocomposites are then summarized. In addition, general strategies applied for surface functionalization of TMDCs are also discussed. Finally, current challenges and future perspectives for these promising materials in biosystem applications are outlined.
KW - biomedical applications
KW - functionalization
KW - nanomaterial design
KW - synthesis
KW - transition-metal dichalcogenides
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U2 - 10.1002/smtd.201700220
DO - 10.1002/smtd.201700220
M3 - Review article
AN - SCOPUS:85091729986
VL - 1
JO - Small Methods
JF - Small Methods
SN - 2366-9608
IS - 12
M1 - 1700220
ER -