Design of CTP-PRO study (impact of stress Cardiac computed Tomography myocardial Perfusion on downstream resources and PROgnosis in patients with suspected or known coronary artery disease: A multicenter international study)

Gianluca Pontone, Carlo De Cecco, Andrea Baggiano, Andrea I. Guaricci, Marco Guglielmo, Tim Leiner, Joao Lima, Pál Maurovich-Horvat, Giuseppe Muscogiuri, John W. Nance, U. Joseph Schoepf

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: CT myocardial perfusion imaging (CTP) represents one of the newly developed CT-based techniques but its cost-effectiveness in the clinical pathway is undefined. The aim of the study is to evaluate the usefulness of combined evaluation of coronary anatomy and myocardial perfusion in intermediate to high-risk patients for suspected CAD or with known disease in terms of clinical decision-making, resource utilization and outcomes in a broad variety of geographic areas and patient subgroups. Methods: CTP-PRO study is a cooperative, international, multicentre, prospective, open-label, randomized controlled study evaluating the cost-effectiveness of a CCTA+CTP strategy (Group A) versus usual care (Group B) in intermediate-high risk patients with suspected or known CAD who undergo clinically indicated diagnostic evaluation. A total sample size of 2000 subjects will be enrolled and followed up for 24 months. The primary endpoint is the reclassification rate of CCTA in group A due to the addition of CTP. The secondary endpoint will be the comparison between groups in terms of non-invasive and invasive downstream testing, prevalence of obstructive CAD at ICA, revascularization, cumulative ED and overall cost during the follow-up at 1- and 2-years. The tertiary endpoint will be the comparison between each group in terms of MACE and cost-effectiveness at 1- and 2-years. Conclusions: The study will provide information to patients, health care providers and other stakeholders about which strategy could be more effective in the diagnosis of suspected CAD in intermediate to high-risk patients or in the symptomatic patients with known CAD and previous history of revascularization.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalInternational Journal of Cardiology
Volume292
DOIs
StatePublished - Oct 1 2019

Keywords

  • Cardiac computed tomography angiography
  • Computed tomography perfusion
  • Coronary artery disease
  • Invasive coronary angiography
  • Major adverse cardiac events
  • Non-invasive test

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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