Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Craig M. Pratt; Robert Gibson; William Boden; Pierre Theroux; Hans Strauss; Mihai Gheorghiade; Robert Capone; Michael Crawford; Robert Schlant; Daniel Arensberg; Robert Kleiger; M. Benjamin Perryman; Kenneth Schechtman; Phillip Young; Robert Roberts

doi:10.1016/S0002-9149(86)80008-X

Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Craig M. Pratt, Robert Gibson, William Boden, Pierre Theroux, Hans Strauss, Mihai Gheorghiade, Robert Capone, Michael Crawford, Robert Schlant, Daniel Arensberg, Robert Kleiger, M. Benjamin Perryman, Kenneth Schechtman, Phillip Young, Robert Roberts

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.

Original language	English (US)
Pages (from-to)	906-910
Number of pages	5
Journal	The American Journal of Cardiology
Volume	58
Issue number	10
DOIs	https://doi.org/10.1016/S0002-9149(86)80008-X
State	Published - Nov 1 1986

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(86)80008-X

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Pratt, C. M., Gibson, R., Boden, W., Theroux, P., Strauss, H., Gheorghiade, M., Capone, R., Crawford, M., Schlant, R., Arensberg, D., Kleiger, R., Benjamin Perryman, M., Schechtman, K., Young, P., & Roberts, R. (1986). Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study. The American Journal of Cardiology, 58(10), 906-910. https://doi.org/10.1016/S0002-9149(86)80008-X

Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study. / Pratt, Craig M.; Gibson, Robert; Boden, William et al.
In: The American Journal of Cardiology, Vol. 58, No. 10, 01.11.1986, p. 906-910.

Research output: Contribution to journal › Article › peer-review

Pratt, CM, Gibson, R, Boden, W, Theroux, P, Strauss, H, Gheorghiade, M, Capone, R, Crawford, M, Schlant, R, Arensberg, D, Kleiger, R, Benjamin Perryman, M, Schechtman, K, Young, P & Roberts, R 1986, 'Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study', The American Journal of Cardiology, vol. 58, no. 10, pp. 906-910. https://doi.org/10.1016/S0002-9149(86)80008-X

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abstract = "This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.",

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AU - Gibson, Robert

AU - Boden, William

AU - Theroux, Pierre

AU - Strauss, Hans

AU - Gheorghiade, Mihai

AU - Capone, Robert

AU - Crawford, Michael

AU - Schlant, Robert

AU - Arensberg, Daniel

AU - Kleiger, Robert

AU - Benjamin Perryman, M.

AU - Schechtman, Kenneth

AU - Young, Phillip

AU - Roberts, Robert

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Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

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