Design maps for scaffold constructs in bone regeneration

Shivakumar I. Ranganathan, Mauro Ferrari, Paolo Decuzzi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In this article, we propose a methodology for the rational design of scaffold constructs in bone-tissue engineering. The construct under investigation is a sandwich structure with an Intramedullary rod (IM), a Biological Sponge (BS) and an External sleeve (ES). The IM rod provides axial resistance, BS facilitates the growth of new bone and ES provides stability to the construct by resisting torsion and bending. We demonstrate that only select combinations of stiffness between IM and ES facilitate the growth of new bone. Perren's interfragmentary strain theory is employed to clearly identify regions favoring bone growth from those favoring the formation of cartilage. Finally, design maps are constructed that clearly identify the combinations facilitating timely bone growth.

Original languageEnglish (US)
Pages (from-to)1005-1013
Number of pages9
JournalBiomedical Microdevices
Volume15
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • Biological sponge
  • Design maps
  • External sleeve
  • Intramedullary rod
  • Scaffolds

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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