Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

Junyan Han; Tae Hoon Lee; Ching Hsuan Tung; Daniel Y. Lee

doi:10.1039/c4ob01981d

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

Junyan Han, Tae Hoon Lee, Ching Hsuan Tung, Daniel Y. Lee

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.

Original language	English (US)
Pages (from-to)	9793-9796
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	48
DOIs	https://doi.org/10.1039/c4ob01981d
State	Published - Dec 28 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c4ob01981d

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title = "Design and synthesis of a mitochondria-targeting carrier for small molecule drugs",

abstract = "A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.",

author = "Junyan Han and Lee, \{Tae Hoon\} and Tung, \{Ching Hsuan\} and Lee, \{Daniel Y.\}",

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AU - Han, Junyan

AU - Lee, Tae Hoon

AU - Tung, Ching Hsuan

AU - Lee, Daniel Y.

PY - 2014/12/28

Y1 - 2014/12/28

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AB - A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.

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AN - SCOPUS:84911911028

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ER -

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

Abstract

ASJC Scopus subject areas

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