Abstract
A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.
Original language | English (US) |
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Pages (from-to) | 9793-9796 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 48 |
DOIs | |
State | Published - Dec 28 2014 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry