Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

Junyan Han, Tae Hoon Lee, Ching Hsuan Tung, Daniel Y. Lee

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.

Original languageEnglish (US)
Pages (from-to)9793-9796
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number48
DOIs
StatePublished - Dec 28 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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