Desensitization strategies: is it worth it?

Sarat Kuppachi, David A. Axelrod

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Preformed donor-specific antibodies (DSAs) limit access to transplantation for thousands of renal transplant patients. While kidney paired donation offers the best strategy for patients with a living donor, for very highly sensitized patients and those without living donors, a strategy of desensitization offers the best hope of transplantation. Removal of DSAs with plasmapheresis, intravenous immunoglobulin and anti-CD20 antibodies can permit successful transplantation. While the clinical outcomes remain inferior to compatible transplant and the costs are significantly greater, when compared with long-term dialysis treatment, these strategies are offer improved survival and are cost-effective given nationally accepted benchmarks.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalTransplant International
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • desensitization
  • donor-specific antibody
  • economic analysis
  • kidney transplant

ASJC Scopus subject areas

  • Transplantation

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