Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid

Francesco Di Pierro; Aswin Thacharodi; Muthiah Kumaraswami; Alexander Bertuccioli; Maria Laura Tanda; Nicola Zerbinati

doi:10.1128/mra.00355-25

Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid

Francesco Di Pierro, Aswin Thacharodi, Muthiah Kumaraswami, Alexander Bertuccioli, Maria Laura Tanda, Nicola Zerbinati

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The draft genome of Streptococcus salivarius eK12, a derivative of the strain K12 with a modified plasmid (pRSSL1), is presented. eK12 was engineered to enhance its probiotic properties against S. pyogenes (GAS) by modulating salivabactin production and interfering with a GAS quorum sensing pathway.

Original language	English (US)
Journal	Microbiology Resource Announcements
Volume	14
Issue number	8
DOIs	https://doi.org/10.1128/mra.00355-25
State	Published - Aug 2025

Keywords

engineered probiotic
salivabactin
speB

ASJC Scopus subject areas

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

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10.1128/mra.00355-25

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Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid. / Pierro, Francesco Di; Thacharodi, Aswin; Kumaraswami, Muthiah et al.
In: Microbiology Resource Announcements, Vol. 14, No. 8, 08.2025.

Research output: Contribution to journal › Article › peer-review

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Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid

Abstract

Keywords

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