TY - JOUR
T1 - Deriving indicators for breast conserving surgery using finite element analysis
AU - Thanoon, D.
AU - Garbey, M.
AU - Bass, B. L.
N1 - Funding Information:
This research work was funded by The Methodist Hospital Research Institute of the Texas Medical Center. We would like to thank Professor Nam-Ho Kim from the University of Florida for his advice on using the ANSYS finite element software.
Publisher Copyright:
© 2013, © 2013 Taylor & Francis.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2015/4/4
Y1 - 2015/4/4
N2 - Breast conserving therapy (BCT), comprising a complete surgical excision of the tumour (partial mastectomy) with post-operative radiotherapy to the remaining breast tissue, is feasible for most women undergoing treatment for breast cancer. The goal of BCT is to achieve local control of the cancer, as well as to preserve a breast that satisfies a woman's cosmetic concerns. Although most women undergo partial mastectomy with satisfactory cosmetic results, in many patients the remaining breast is left with major cosmetic defects including concave deformities, distortion of the nipple–areolar complex, asymmetry and changes in tissue density characterised by excessive density associated with parenchymal scarring, as well as breast pain. There are currently no tools, other than surgical experience and judgement, which can predict the impact of partial mastectomy on the contour, the deformity of the treated breast and the mechanical stress that it induces. In this study, we use a finite element model to execute virtual surgery and carry out a sensitivity analysis on the resection location, the resection size, the breast tissue mechanical property and the different post-surgery recovery stage. We output the result in two different built-in indicators labelled as the cosmetic and the functional indicators. This study used the breast model for three women with breast cancer who have been elected to undergo BCT and are being treated at the Methodist Hospital in Houston, TX. The goal of this study was to propose a first glimpse of the key parameter leading to satisfactory post-BCT cosmetic results.
AB - Breast conserving therapy (BCT), comprising a complete surgical excision of the tumour (partial mastectomy) with post-operative radiotherapy to the remaining breast tissue, is feasible for most women undergoing treatment for breast cancer. The goal of BCT is to achieve local control of the cancer, as well as to preserve a breast that satisfies a woman's cosmetic concerns. Although most women undergo partial mastectomy with satisfactory cosmetic results, in many patients the remaining breast is left with major cosmetic defects including concave deformities, distortion of the nipple–areolar complex, asymmetry and changes in tissue density characterised by excessive density associated with parenchymal scarring, as well as breast pain. There are currently no tools, other than surgical experience and judgement, which can predict the impact of partial mastectomy on the contour, the deformity of the treated breast and the mechanical stress that it induces. In this study, we use a finite element model to execute virtual surgery and carry out a sensitivity analysis on the resection location, the resection size, the breast tissue mechanical property and the different post-surgery recovery stage. We output the result in two different built-in indicators labelled as the cosmetic and the functional indicators. This study used the breast model for three women with breast cancer who have been elected to undergo BCT and are being treated at the Methodist Hospital in Houston, TX. The goal of this study was to propose a first glimpse of the key parameter leading to satisfactory post-BCT cosmetic results.
KW - breast conserving therapy
KW - computational surgery
KW - cosmetic indicator
KW - mechanical stress
KW - soft-tissue mechanics
KW - tissue engineering
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U2 - 10.1080/10255842.2013.820716
DO - 10.1080/10255842.2013.820716
M3 - Article
C2 - 23919823
AN - SCOPUS:84911984720
VL - 18
SP - 533
EP - 544
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
SN - 1025-5842
IS - 5
ER -