Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

Mohamad G. Ghosn; Valery V. Tuchin; Kirill V. Larin

doi:10.1364/OL.31.002314

Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

Mohamad G. Ghosn, Valery V. Tuchin, Kirill V. Larin

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.73 × 10^-6 cm/s at the epithelial side to 8.63±0.27 × 10^-6 cm/s close to the endothelial side of the sciera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sciera with a resolution of approximately 40 μm.

Original language	English (US)
Pages (from-to)	2314-2316
Number of pages	3
Journal	Optics Letters
Volume	31
Issue number	15
DOIs	https://doi.org/10.1364/OL.31.002314
State	Published - Aug 1 2006

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

Access to Document

10.1364/OL.31.002314

Cite this

@article{7a0c8665ce974283895c9cdcd75c3edc,

title = "Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography",

abstract = "We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.73 × 10-6 cm/s at the epithelial side to 8.63±0.27 × 10-6 cm/s close to the endothelial side of the sciera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sciera with a resolution of approximately 40 μm.",

author = "Ghosn, {Mohamad G.} and Tuchin, {Valery V.} and Larin, {Kirill V.}",

year = "2006",

month = aug,

day = "1",

doi = "10.1364/OL.31.002314",

language = "English (US)",

volume = "31",

pages = "2314--2316",

journal = "Optics Letters",

issn = "0146-9592",

publisher = "The Optical Society",

number = "15",

}

TY - JOUR

T1 - Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

AU - Ghosn, Mohamad G.

AU - Tuchin, Valery V.

AU - Larin, Kirill V.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.73 × 10-6 cm/s at the epithelial side to 8.63±0.27 × 10-6 cm/s close to the endothelial side of the sciera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sciera with a resolution of approximately 40 μm.

AB - We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.73 × 10-6 cm/s at the epithelial side to 8.63±0.27 × 10-6 cm/s close to the endothelial side of the sciera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sciera with a resolution of approximately 40 μm.

UR - http://www.scopus.com/inward/record.url?scp=33748458699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748458699&partnerID=8YFLogxK

U2 - 10.1364/OL.31.002314

DO - 10.1364/OL.31.002314

M3 - Article

C2 - 16832470

AN - SCOPUS:33748458699

VL - 31

SP - 2314

EP - 2316

JO - Optics Letters

JF - Optics Letters

SN - 0146-9592

IS - 15

ER -

Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this