Depth-resolved imaging and detection of microretroreflectors within biological tissue using optical coherence tomography

Steven N. Ivers; Stephan A. Baranov; Tim Sherlock; Katerina Kourentzi; Paul Ruchhoeft; Richard Willson; Kirill V. Larin

doi:10.1364/BOE.1.000367

Depth-resolved imaging and detection of microretroreflectors within biological tissue using optical coherence tomography

Steven N. Ivers, Stephan A. Baranov, Tim Sherlock, Katerina Kourentzi, Paul Ruchhoeft, Richard Willson, Kirill V. Larin

Houston Methodist

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue.

Original language	English (US)
Pages (from-to)	367-377
Number of pages	11
Journal	Biomedical Optics Express
Volume	1
Issue number	2
DOIs	https://doi.org/10.1364/BOE.1.000367
State	Published - Sep 1 2010

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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abstract = "A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue.",

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AU - Ivers, Steven N.

AU - Baranov, Stephan A.

AU - Sherlock, Tim

AU - Kourentzi, Katerina

AU - Ruchhoeft, Paul

AU - Willson, Richard

AU - Larin, Kirill V.

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Depth-resolved imaging and detection of microretroreflectors within biological tissue using optical coherence tomography

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