Depth-resolved imaging and detection of microretroreflectors within biological tissue using optical coherence tomography

Steven N. Ivers, Stephan A. Baranov, Tim Sherlock, Katerina Kourentzi, Paul Ruchhoeft, Richard Willson, Kirill V. Larin

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue.

Original languageEnglish (US)
Pages (from-to)367-377
Number of pages11
JournalBiomedical Optics Express
Volume1
Issue number2
DOIs
StatePublished - Sep 1 2010

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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