Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease

Mario F. Dulay, Adriana M. Strutt, Harvey S. Levin, Joseph Jankovic, Eugene C. Lai, Robert G. Grossman, Michele K. York

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson's disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson's disease surgical candidates both before and after surgery.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume20
Issue number3
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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