Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease

Mario F. Dulay; Adriana M. Strutt; Harvey S. Levin; Joseph Jankovic; Eugene C. Lai; Robert G. Grossman; Michele K. York

doi:10.1176/jnp.2008.20.3.357

Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease

Mario F. Dulay, Adriana M. Strutt, Harvey S. Levin, Joseph Jankovic, Eugene C. Lai, Robert G. Grossman, Michele K. York

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson's disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson's disease surgical candidates both before and after surgery.

Original language	English (US)
Pages (from-to)	357-363
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	20
Issue number	3
DOIs	https://doi.org/10.1176/jnp.2008.20.3.357
State	Published - 2008

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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abstract = "This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson's disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson's disease surgical candidates both before and after surgery.",

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AU - Dulay, Mario F.

AU - Strutt, Adriana M.

AU - Levin, Harvey S.

AU - Jankovic, Joseph

AU - Lai, Eugene C.

AU - Grossman, Robert G.

AU - York, Michele K.

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Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease

Abstract

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