TY - JOUR
T1 - Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency Cohort
AU - Jovanovich, Anna
AU - Cai, Xuan
AU - Frazier, Rebecca
AU - Bundy, Josh D.
AU - He, Jiang
AU - Rao, Panduranga
AU - Lora, Claudia
AU - Dobre, Mirela
AU - Go, Alan
AU - Shafi, Tariq
AU - Feldman, Harold I.
AU - Rhee, Eugene P.
AU - Miyazaki, Makoto
AU - Isakova, Tamara
AU - Chonchol, Michel
N1 - Funding Information:
This work was supported by the George M. O’Brien Kidney Research Center at Northwestern University (NU-GoKIDNEY; P30DK114857) from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). A.J. is supported by Veterans Affairs Merit Award I01CX001985. R.F. is supported by grant T32DK108738 from the NIDDK. T.I. is supported by grants R01DK102438, R01DK110087, and U01DK099930 from the NIDDK and K24HL150235 from the National Heart, Lung, and Blood Institute. Funding for the CRIC study was obtained under a cooperative agreement from the National Institute of Diabetes and Digestive and Kidney Diseases (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902 and U24DK060990). In addition, this work was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award NIH/NCATS UL1TR000003, Johns Hopkins University UL1 TR-000424, University of Maryland GCRC M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland, UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the NIH and NIH roadmap for Medical Research, Michigan Institute for Clinical and Health Research (MICHR) UL1TR000433, University of Illinois at Chicago CTSA UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, Kaiser Permanente NIH/NCRR UCSF-CTSI UL1 RR-024131, Department of Internal Medicine, University of New Mexico School of Medicine Albuquerque, NM R01DK119199.
Publisher Copyright:
© 2022 The Authors.
PY - 2022/4/5
Y1 - 2022/4/5
N2 - BACKGROUND: Deoxycholic acid (DCA) is a secondary bile acid that may promote vascular calcification in experimental settings. Higher DCA levels were associated with prevalent coronary artery calcification (CAC) in a small group of individuals with advanced chronic kidney disease. Whether DCA levels are associated with CAC prevalence, incidence, and progression in a large and diverse population of individuals with chronic kidney disease stages 2 to 4 is unknown. METHODS AND RESULTS: In the CRIC (Chronic Renal Insufficiency Cohort) study, we evaluated cross-sectional (n=1057) and longitudinal (n=672) associations between fasting serum DCA levels and computed tomographic CAC using multivariable-adjusted regression models. The mean age was 57±12 years, 47% were women, and 41% were Black. At baseline, 64% had CAC (CAC score >0 Agatston units). In cross-sectional analyses, models adjusted for demographics and clinical factors showed no association between DCA levels and CAC >0 compared with no CAC (prevalence ratio per 1-SD higher log DCA, 1.08 [95% CI, 0.91–1.26). DCA was not associated with incident CAC (incidence per 1-SD greater log DCA, 1.08 [95% CI, 0.85–1.39]) or CAC progression (risk for increase in ≥100 and ≥200 Agatston units per year per 1-SD greater log DCA, 1.05 [95% CI, 0.84–1.31] and 1.26 [95% CI, 0.77–2.06], respectively). CONCLUSIONS: Among CRIC study participants, DCA was not associated with prevalent, incident, or progression of CAC.
AB - BACKGROUND: Deoxycholic acid (DCA) is a secondary bile acid that may promote vascular calcification in experimental settings. Higher DCA levels were associated with prevalent coronary artery calcification (CAC) in a small group of individuals with advanced chronic kidney disease. Whether DCA levels are associated with CAC prevalence, incidence, and progression in a large and diverse population of individuals with chronic kidney disease stages 2 to 4 is unknown. METHODS AND RESULTS: In the CRIC (Chronic Renal Insufficiency Cohort) study, we evaluated cross-sectional (n=1057) and longitudinal (n=672) associations between fasting serum DCA levels and computed tomographic CAC using multivariable-adjusted regression models. The mean age was 57±12 years, 47% were women, and 41% were Black. At baseline, 64% had CAC (CAC score >0 Agatston units). In cross-sectional analyses, models adjusted for demographics and clinical factors showed no association between DCA levels and CAC >0 compared with no CAC (prevalence ratio per 1-SD higher log DCA, 1.08 [95% CI, 0.91–1.26). DCA was not associated with incident CAC (incidence per 1-SD greater log DCA, 1.08 [95% CI, 0.85–1.39]) or CAC progression (risk for increase in ≥100 and ≥200 Agatston units per year per 1-SD greater log DCA, 1.05 [95% CI, 0.84–1.31] and 1.26 [95% CI, 0.77–2.06], respectively). CONCLUSIONS: Among CRIC study participants, DCA was not associated with prevalent, incident, or progression of CAC.
KW - chronic kidney disease
KW - coronary artery calcification
KW - deoxycholic acid
KW - microbiome
KW - secondary bile acid
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U2 - 10.1161/JAHA.121.022891
DO - 10.1161/JAHA.121.022891
M3 - Article
C2 - 35322682
AN - SCOPUS:85128245088
SN - 2047-9980
VL - 11
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 7
M1 - e022891
ER -