Demyelinating optic neuritis presenting as a clinically isolated syndrome

Nicky R. Holdeman, Tammy Nguyen, Rosa A. Tang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Clinically isolated syndrome (CIS) describes a single, first-occurrence attack caused by inflammation/demyelination in 1 or more locations in the central nervous system. The optic nerve is a frequent site affected by this neurologic event. As the name implies, CIS is an isolated condition but is often considered a precursor to multiple sclerosis (MS). When distinctive brain lesions detected by magnetic resonance imaging (MRI) accompany CIS, the person is considered at a high risk for MS. Treatment is aimed at delaying the onset of a second neurologic episode, reducing the accumulation of MRI-detected brain lesions and delaying the development of definite MS. Case Report: This article describes a 40-year-old woman who experienced a sudden loss of vision in the right eye. Testing ultimately found a normal MRI, demyelination of the optic nerve, and progressive thinning of the retinal nerve fiber layer, leading to a diagnosis of CIS.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
Issue number1
StatePublished - Jan 2012


  • Clinically isolated syndrome
  • Demyelination
  • Immunomodulators
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Optic neuritis
  • Optical coherence tomography

ASJC Scopus subject areas

  • Optometry


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