TY - JOUR
T1 - Delivery strategies of RNA therapeutics to leukocytes
AU - Tarab-Ravski, Dana
AU - Stotsky-Oterin, Lior
AU - Peer, Dan
N1 - Funding Information:
This work was supported in part by a grant from the Boaz and Varda Dotan Hemato-oncology Center at Tel Aviv University.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/2
Y1 - 2022/2
N2 - Harnessing RNA-based therapeutics for cancer, inflammation, and viral diseases is hindered by poor delivery of therapeutic RNA molecules. Targeting leukocytes to treat these conditions holds great promise, as they are key participants in their initiation, drug response, and treatment. The various extra- and intra-cellular obstacles that impediment the clinical implementation of therapeutic RNA can be overcome by utilizing drug delivery systems. However, delivery of therapeutic RNA to leukocytes poses an even greater challenge as these cells are difficult to reach and transfect upon systemic administration. This review briefly describes the existing successful delivery strategies that efficiently target leukocytes in vivo and discuss their potential clinical applicability.
AB - Harnessing RNA-based therapeutics for cancer, inflammation, and viral diseases is hindered by poor delivery of therapeutic RNA molecules. Targeting leukocytes to treat these conditions holds great promise, as they are key participants in their initiation, drug response, and treatment. The various extra- and intra-cellular obstacles that impediment the clinical implementation of therapeutic RNA can be overcome by utilizing drug delivery systems. However, delivery of therapeutic RNA to leukocytes poses an even greater challenge as these cells are difficult to reach and transfect upon systemic administration. This review briefly describes the existing successful delivery strategies that efficiently target leukocytes in vivo and discuss their potential clinical applicability.
KW - Drug delivery
KW - Leukocytes
KW - Nanocarriers
KW - RNA
KW - mRNA
KW - Nanoparticles
KW - RNA Interference
KW - Humans
KW - RNA, Small Interfering/genetics
KW - Neoplasms/drug therapy
KW - Drug Delivery Systems
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U2 - 10.1016/j.jconrel.2022.01.016
DO - 10.1016/j.jconrel.2022.01.016
M3 - Review article
C2 - 35041904
AN - SCOPUS:85123031442
SN - 0168-3659
VL - 342
SP - 362
EP - 371
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -