Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

Yasmin Granot, Dan Peer

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

mRNA molecules hold tremendous potential as a tool for gene therapy of a wide range of diseases. However, the main hurdle in implementation of mRNA for therapeutics, the systemic delivery of mRNA molecules to target cells, remains a challenge. A feasible solution for this challenge relies in the rapidly evolving field of nucleic acid-loaded nanocarriers and specifically in the established family of lipid-based nanoparticles (LNPs). Herein, we will discuss the main factors, which determine the fate of modified mRNA (mmRNA)-loaded LNPs in-vivo, and will focus on their interactions with the innate immune system as a main consideration in the design of lipid-based mmRNA delivery platforms.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalSeminars in Immunology
Volume34
DOIs
StatePublished - Dec 2017

Keywords

  • Lipid nanoparticles
  • Mononuclear phagocytic system
  • Pattern recognition receptors
  • RNA modifications
  • Systemic delivery
  • mRNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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