Delineation of the androgen-regulated signaling pathways in prostate cancer facilitates the development of novel therapeutic approaches

Dominik Awad, Thomas L. Pulliam, Chenchu Lin, Sandi R. Wilkenfeld, Daniel E. Frigo

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Although androgen deprivation therapy (ADT) is initially effective for the treatment of progressive prostate cancer, it inevitably fails due to the onset of diverse resistance mechanisms that restore androgen receptor (AR) signaling. Thus, AR remains a desired therapeutic target even in the relapsed stages of the disease. Given the difficulties in stopping all AR reactivation mechanisms, we propose that the identification of the driver signaling events downstream of the receptor offer viable, alternative therapeutic targets. Here, we summarize recently described, AR-regulated processes that have been demonstrated to promote prostate cancer. By highlighting these signaling events and describing some of the ongoing efforts to pharmacologically modulate these pathways, our goal is to advocate potential new therapeutic targets that would represent an alternative approach for blocking AR actions.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalCurrent Opinion in Pharmacology
Volume41
DOIs
StatePublished - Aug 2018

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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