Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

C. Daniel De Magalhaes Filho, Laurent Kappeler, Joëlle Dupont, Julien Solinc, Sonia Villapol, Cécile Denis, Marika Nosten-Bertrand, Jean Marie Billard, Annick Blaise, François Tronche, Bruno Giros, Christiane Charriaut-Marlangue, Saba Aïd, Yves Le Bouc, Martin Holzenberger

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth factor signaling also impacts on neurogenesis, neuronal survival and structural plasticity. Recent reports demonstrated that diminished insulin-like growth factor signaling confers increased stress resistance in brain and other tissues. To better understand the role of neuronal insulin-like growth factor signaling in neuroprotection, we inactivated insulin-like growth factor type-1-receptor in forebrain neurons using conditional Cre-LoxP-mediated gene targeting. We found that brain structure and function, including memory performance, were preserved in insulin-like growth factor receptor mutants, and that certain characteristics improved, notably synaptic transmission in hippocampal neurons. To reveal stress-related roles of insulin-like growth factor signaling, we challenged the brain using a stroke-like insult. Importantly, when charged with hypoxia-ischemia, mutant brains were broadly protected from cell damage, neuroinflammation and cerebral edema. We also found that in mice with insulin-like growth factor receptor knockout specifically in forebrain neurons, a substantial systemic upregulation of growth hormone and insulin-like growth factor-I occurred, which was associated with significant somatic overgrowth. Collectively, we found strong evidence that blocking neuronal insulin-like growth factor signaling increases peripheral somatotropic tone and simultaneously protects the brain against hypoxic-ischemic injury, findings that may contribute to developing new therapeutic concepts preventing the disabling consequences of stroke.

Original languageEnglish (US)
Pages (from-to)396-412
Number of pages17
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
StatePublished - 2016


  • Cerebral edema
  • hypoxia-ischemia
  • insulin-like growth factor
  • neuroinflammation
  • neuroprotection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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