@article{a89c0ec9a2d844868457b22a9c30563d,
title = "Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression",
abstract = "Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development ofAIDS (33% vs. 17%), or death (18% vs. 9%) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status.",
author = "{The Department of Veterans Affairs Cooperative Study Group} and Gordin, {Fred M.} and Hartigan, {Pamela M.} and Klimas, {Nancy G.} and Pazner, {Susan B.Zolla} and Simberkoff, {Michael S.} and Hamilton, {John D.} and Houston, {V. A.} and M. Griffin and K. Harper and Lahart, {C. J.} and D. Musher and A. Peacock and R. Rossen and J. Thomas and J. Wilson and Wray, {N. P.} and V. Allsup and C. Austin and E. Crawford and R. Endow and S. Finegold and J. Fleischman and George, {W. L.} and O′brien, {W. A.} and M. Oliver and D. Reeves and C. Silbar and Dickinson, {G. M.} and R. Greenman and J. Meager and J. Mix and R. Mendez and G. Paperwalla and M. Smith and E. Bailey and Diamond, {G. R.} and W. Ei-Sadr and V. Gianakakos and N. Haren and J. O′leary and A. Cotleur and G. Gilliland and R. Jalbert and Jensen, {P. C.} and M. Marovich and Ziegler, {J. L.} and D. Bille and C. Ebersole and E. Greenberg and Hawkes, {C. A.}",
note = "Funding Information: Received 3 August 1993; revised 29 November 1993. Presented in part: 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 14 October 1992, Anaheim, California (abstract 1348). Informed consent was obtained from patients or their guardians, and human experimentation guidelines of the US Department of Health and Human Services and those of the authors' institutions were followed. Financial support: Cooperative Studies Program, Medical Research Service. Department of Veterans Affairs, and the US Army Medical Research and Development Command. Reprints or correspondence: Dr. Fred M. Gordin, Infectious Diseases, VA Medical Center, 50 Irving St., N.W., Washington, IX' 20422. * Study group members are listed after text.",
year = "1994",
month = apr,
doi = "10.1093/infdis/169.4.893",
language = "English (US)",
volume = "169",
pages = "893--897",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}