Delayed onset of retinopathy of prematurity associated with mitochondrial dysfunction and pearson syndrome

Nimesh A. Patel; Elaine Han; Nicolas A. Yannuzzi; Kenneth C. Fan; Catherin I. Negron; Supalert Prakhunhungsit; Carlos E. Mendoza-Santiesteban; Audina M. Berrocal

doi:10.3928/01913913-20190813-01

Delayed onset of retinopathy of prematurity associated with mitochondrial dysfunction and pearson syndrome

Nimesh A. Patel, Elaine Han, Nicolas A. Yannuzzi, Kenneth C. Fan, Catherin I. Negron, Supalert Prakhunhungsit, Carlos E. Mendoza-Santiesteban, Audina M. Berrocal

Houston Methodist

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP.

Original language	English (US)
Pages (from-to)	E60-E64
Journal	Journal of Pediatric Ophthalmology and Strabismus
Volume	56
Issue number	6
DOIs	https://doi.org/10.3928/01913913-20190813-01
State	Published - Oct 17 2019

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

Access to Document

10.3928/01913913-20190813-01

Cite this

@article{6ca063e0ee15427a8b591aa7f0d2e2da,

title = "Delayed onset of retinopathy of prematurity associated with mitochondrial dysfunction and pearson syndrome",

abstract = "Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP.",

author = "Patel, {Nimesh A.} and Elaine Han and Yannuzzi, {Nicolas A.} and Fan, {Kenneth C.} and Negron, {Catherin I.} and Supalert Prakhunhungsit and Mendoza-Santiesteban, {Carlos E.} and Berrocal, {Audina M.}",

note = "Publisher Copyright: Copyright {\textcopyright} SLACK Incorporated.",

year = "2019",

month = oct,

day = "17",

doi = "10.3928/01913913-20190813-01",

language = "English (US)",

volume = "56",

pages = "E60--E64",

journal = "Journal of Pediatric Ophthalmology and Strabismus",

issn = "0191-3913",

publisher = "Slack Incorporated",

number = "6",

}

TY - JOUR

T1 - Delayed onset of retinopathy of prematurity associated with mitochondrial dysfunction and pearson syndrome

AU - Patel, Nimesh A.

AU - Han, Elaine

AU - Yannuzzi, Nicolas A.

AU - Fan, Kenneth C.

AU - Negron, Catherin I.

AU - Prakhunhungsit, Supalert

AU - Mendoza-Santiesteban, Carlos E.

AU - Berrocal, Audina M.

PY - 2019/10/17

Y1 - 2019/10/17

N2 - Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP.

AB - Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP.

UR - http://www.scopus.com/inward/record.url?scp=85073544686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073544686&partnerID=8YFLogxK

U2 - 10.3928/01913913-20190813-01

DO - 10.3928/01913913-20190813-01

M3 - Article

C2 - 31622479

AN - SCOPUS:85073544686

SN - 0191-3913

VL - 56

SP - E60-E64

JO - Journal of Pediatric Ophthalmology and Strabismus

JF - Journal of Pediatric Ophthalmology and Strabismus

IS - 6

ER -

Delayed onset of retinopathy of prematurity associated with mitochondrial dysfunction and pearson syndrome

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this