Delay in invasive risk stratification of women with acute coronary syndrome is associated with worse outcomes

Mouaz Husayn Al-Mallah, Rasha N. Bazari, Sanjaya Khanal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Invasive risk stratification in patients with acute coronary syndromes (ACS) has been shown to improve outcomes. There is paucity of data on women undergoing invasive risk stratification. We investigated whether the time to coronary angiography affects survival of female patients admitted with ACS. Method: Female patients admitted to the coronary intensive care unit with ACS between 1/1/97 and 12/31/00 and undergoing coronary angiography during same hospitalization were divided into three groups based on the time to angiography: same day, 1-2 days and >2 days. The baseline clinical features, angiography results and outcomes were compared between the angiography groups. Results: Of the total 350 female patients who fulfilled the inclusion criteria, 63% underwent angiography within two days of presentation. Three year mortality rates in women undergoing angiography on the same day, 1-2 days and >2-days were 7%, 7% and 22% respectively (p = 0.001). Using multivariate analysis, angiography beyond 2 days was a significant predictor of mortality among women (OR 2.6, 95% CI 1.3-5.0, p = 0.006) after adjusting for confounding variables. Conclusion: Later invasive risk stratification after 2 days of presentation in women with ACS is associated with worse survivial. Gender should not be a reason to defer early coronary angiography in these patients.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Volume23
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

Keywords

  • Acute coronary syndrome
  • Coronary angiography
  • Outcome
  • Women

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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