Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study

Moran Amit, Shorook Na'ara, Leonor Trejo–Leider, Naomi Ramer, David Burstein, Ma Yue, Brett Miles, Xinjie Yang, Delin Lei, Kristine Bjoerndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Snehal Patel, Ian Ganly, Ziv Gil

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: The mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck. Methods: We conducted univariate and multivariate analyses of international data. Results: Data of 507 patients with ACC of the head and neck were analyzed; negative margins defined as ≥5 mm were detected in 253 patients (50%). On multivariate analysis, the hazard ratios (HRs) of positive margin status were 2.68 (95% confidence interval [CI], 1.2–6.2; p =.04) and 2.63 (95% CI, 1.1–6.3; p =.03) for overall survival (OS) and disease-specific survival (DSS), respectively. Close margins had no significant impact on outcome, with HRs of 1.1 (95% CI, 0.4–3.0; p =.12) and 1.07 (95% CI, 0.3–3.4; p =.23) for OS and DSS, respectively, relative with negative margins. Conclusion: In head and neck ACC, positive margins are associated with the worst outcome. Negative or close margins are associated with improved outcome, regardless of the distance from the tumor.

Original languageEnglish (US)
Pages (from-to)1008-1014
Number of pages7
JournalHead and Neck
Volume39
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • adenoid cystic carcinoma
  • head and neck cancer
  • margins
  • oral cavity
  • paranasal sinuses
  • salivary gland
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study'. Together they form a unique fingerprint.

Cite this