Defining the outcome of patients with delayed diagnosis of differentiated thyroid cancer

Moran Amit, Yaron Rudnicki, Yoav Binenbaum, Leonor Trejo-Leider, Jacob T. Cohen, Ziv Gil

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objectives/Hypothesis: In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC).

Study Design: Retrospective medical record review and analysis of survival outcomes.

Methods: The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome.

Results: Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n=162) who underwent immediate surgery for similar disease.

Conclusions: We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome.

Original languageEnglish (US)
Pages (from-to)2837-2840
Number of pages4
Issue number12
StatePublished - Dec 1 2014


  • Delayed
  • Fine-needle aspiration
  • Observation
  • Papillary
  • Surgery
  • Thyroid

ASJC Scopus subject areas

  • Otorhinolaryngology


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